Paget's disease is a chronic bone disorder that is caused by the irregular breakdown and regrowth of bone tissue. It can lead to enlarged and misshapen bones which can further lead to other bone and joint problems. It usually occurs in one bone but can involve many bones. Paget's disease is rarely diagnosed in people under 40 years of age. Men and women are approximately equally affected.
Alternative Names: Osteitis deformans.
Complications of Paget's disease
Causes of Paget's disease
The cause of Paget's disease is unknown, although it is considered to be linked with genes or a viral infection at young age.
Signs & Symptoms of Paget's disease
Most patients have no symptoms. Sometimes, symptoms may be confused with those of arthritis or other disorders. In other cases, the diease is diagnosed only after complications have developed.
Symptoms can include:
Diagnosis of Paget's disease
Treatments of Paget's disease
Treatment is not required for all patients. For example, only patients who have abnormal blood tests may need treatment.
However treatment will be required for the following:
1) Drug therapy: Drugs help prevent further bone breakdown.
Various types of drugs that are used are :
- Bisphosphonates: These drugs help to increase bone density.
Types of bisphosphonates include:
a) Alendronate (Fosamax)
b) Etidronate (Didronel)
c) Pamidronate (Aredia)
d) Risedronate (Actonel)
e) Tiludronate (Skelid)
f) Zoledronic acid (Zometa)
- Calcitonin : It is atype of hormone involved in bone metabolism.
Types of calcitonin include:
a) Intranasal (Miacalcin)
b) Subcutaneous (Calcimar)
- Plicamycin (Mithracin)
- NSAIDS: Non-Steroidal Anti-Inflammatory Drugs or analgesics may also be given for pain.
2) Orthopedic surgery - It may be required to correct a specific deformity in severe cases.
Prevention of Paget's disease
When to seek Medical Advice
Whenever you develop symptoms of paget's disease.