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Alport syndrome is an inherited disorder that damages tiny blood vessels in the kidneys.
Alternative Names of Alport's Syndrome are: Hereditary nephritis; Hematuria - nephropathy - deafness; Hemorrhagic familial nephritis; hereditary deafness and nephropathy.
Complications of Alport's Syndrome
Causes of Alport's Syndrome
Alport syndrome is an inherited form of kidney inflammation (nephritis). It is caused by a mutation in a gene for a protein in connective tissue, called collagen. The disorder is uncommon, and most often affects males. Women can transmit the gene for the disorder to their children, even if they have no symptoms.
Risk factors include:
Signs & Symptoms of Alport's Syndrome
The disorder damages the tiny blood vessels in the kidneys, called glomeruli that filter wastes. At first, there are no symptoms. However, progressive destruction of the glomeruli leads to blood in the urine and may decrease the effectiveness of the kidney's filtering system. There is a progressive loss of kidney function and a build-up of fluids and waste products in the body. In women, the disorder is usually mild, with minimal or no symptoms. In men, the symptoms are more severe and get worse faster.
The condition can progress to end-stage renal disease (ESRD) at an early age (between adolescence and age 40).
Note: There may be no symptoms in some cases. Symptoms of chronic kidney failure or heart failure may be present or may develop.
Diagnosis of Alport's Syndrome
The following tests may be done:
Treatments of Alport's Syndrome
Prevention of Alport's Syndrome
This uncommon disorder is inherited. Awareness of risk factors, such as a family history of the disorder, may allow the condition to be detected early.
When to seek Medical Advice
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